Membrane-stabilizing drugs inhibiting short-term desensitization induced by histamine in guinea-pig taenia caecum.
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منابع مشابه
The beta3-adrenoceptor-mediated relaxation induced by dopamine in guinea pig taenia caecum.
The mechanisms of the beta-adrenoceptor-mediated relaxation induced by dopamine in guinea pig taenia caecum were examined. The relaxant response to dopamine was unaffected by propranolol (10(-8)-10(-5) M) or phentolamine (10(-8)-10(-5) M). Atenolol (3 x 10(-7)-3 x 10(-4) M), butoxamine (10(-7)-10(-4) M), prazosin (10(-8)-10(-5) M), yohimbine (10(-8)-10(-5) M), SCH 23390 (10(-8)-10(-5) M) and ha...
متن کاملSignal transduction pathway involved in beta 3-adrenoceptor-mediated relaxation in guinea pig taenia caecum.
Experiments were carried out to examine the components of the intracellular second messenger system that is involved in beta 3-adrenoceptor (atypical beta-adrenoceptors)-mediated relaxation in the guinea pig taenia caecum. Propranolol and butoxamine caused competitive antagonism of the relaxant response to isoprenaline. However, propranolol or butoxamine did not significantly affect the relaxan...
متن کاملCalcium and the contractile effect of carbachol in the depolarized guinea-pig taenia caecum.
Carbachol (10-8-10-3 M) caused a phasic contraction in the guinea-pig taenia caecum suspended in the Ca-free, K-Tyrode solution. The action of carba chol was concentration-related and was completely antagonized by atropine (10-6 g/ml). The capacity to contract in the absence of external Ca was removed by short term exposure to a high concentration of carbachol (...
متن کاملCalcium-induced calcium release mechanism in guinea pig taenia caeci
Fura-2 was used to measure the amount of Ca released from the intracellular Ca store of a saponin-skinned smooth muscle fiber bundle of the guinea pig taenia caeci (width, 150-250 microns) placed in a capillary cuvette at 20-22 degrees C. The amount of Ca actively loaded into the store was assayed when released by the application of 50 mM caffeine and/or 10 microM inositol 1,4,5-trisphosphate (...
متن کاملDesensitization of smooth muscle cells in the guinea pig taenia coli to prolonged application of carbachol.
depolarized the membrane, reduced the membrane resistance and evoked contracture. These responses did not, however, continue but a desensitization to Carb then developed, i. e. the membrane was gradually repolarized, membrane resistance increased, and the muscle relaxed in spite of the presence of Carb. 2. During the repolarization phase in the presence of Carb (10-5 g/ml), repeated current pul...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1985
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)63686-3